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:: Guide to M.D./Ph.D. and Frequently Asked Questions ::

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Frequently Asked Questions (FAQ)

Medical Scientist Training Programs (Preparation, Applying, Choosing)

by Jot Dhadialla

What are the aims of an MD/PhD or MSTP program?
What preparation do I need to successfully be admitted to these programs?
Should I do my research in lab, or try many different labs?
Will excellent research experience make up for a lack of clinical experience?
Does the reputation of my college matter?
What kind of scores do I need?
What are the programs looking for in an applicant?
How competitive is it to get into these programs?
Where should I apply?
Is there a suggested timeline for applicants?
Should I include my interests in research in my AMCAS personal statement?
How important is the secondary information such as the specific medical school essays and MD/PhD essays?
How much will the process cost me, and how much time will it take?
How should I prepare for an interview?
What are the interviews like, and how are they structured?
What should I look for in a program?
What programs are available for International students?

What are the aims of an MD/PhD or MSTP program?

According to the NIH, the aim for MST programs is to produce Physician-Scientists. Essentially, over the past decades, there have been fewer individuals who have been trained in basic science as well as clinical medicine. With a growing need to integrate knowledge and practice, it is essential to produce scientists who are trained in clinical medicine in order to bridge the gap between these worlds.
The need to translate basic research to clinical practice is not a novel idea or problem. As early as the 1850’s, and perhaps before, scientists like Rudolph Virchow (the father of pathophysiology) warned against science with no application – science for the sake of science (Wissenschaft). While the benefits of science for its own sake have proven to be unforeseeable and essential, the concerted efforts and breakthroughs afforded by focused training in science as well as medicine have also proved to be essential.
The NIH initially funded MSTP programs in 1964, in order to address the waning number of students and professionals that were choosing careers that would meet these goals. The track record of these programs has shown that most of the graduates enter academic medicine disciplines, and as a result, the size and investment in these programs by the NIH and alternate funding sources has increased. Those MD/PhD programs that have successfully met the goals of the NIH, which are ascertained during periodic site visits are given a seal of approval, the title of MSTP, and are allocated a certain number of NIH funded seats which covers the tuition required for medical and graduate schools, as well as a stipend. There are currently 39 MSTP programs, while many more MD/PhD programs exist. While it would seem the MSTP programs would have a homogenous structure in order to meet the requirements of the NIH, there is a wide difference in philosophy and structure of the programs, which produce graduates that span the Physician-Scientist continuum. Back to top

What preparation do I need to successfully be admitted to these programs?

The most common answer one would receive to this question is that the preparation needed is not formulaic. Much like medical school admissions, however, there are factors that will greatly enhance ones chance of admission. In addition to have elements common to medical school applicants, research experience makes the foundation of ones application. By the time student’s matriculate into the most competitive programs, many have had around 1.5-2.5 years of research experience. From these research experiences result an important component of ones application: recommendation letters. Some schools weight the letters very highly, and they can become ones greatest ally. Most of the MD/PhD interviews consist of research-centric questions, in addition to justifying the necessity of the double degrees. Most successful MD/PhD applicants have high college GPA’s and scores as well. Though it is possible to get into the most competitive programs with these elements, it always helps to have had unique experiences or awards that set one apart from the pack of highly competitive candidates. It is possible to make up for weaker parts of ones application by strengthening others. Back to top

Should I do my research in lab, or try many different labs?

Undergraduate time is, among many other things, a time to broaden ones knowledge base and experience, in order to ascertain what fields fit best. In fact, most students still do not have strong inclinations regarding their field of PhD research until after medical school begins, which is perfectly acceptable. While it is important to gain broad exposure to research styles, lab techniques, and fields of study, it is also equally important to demonstrate ones commitment to research, and capability for creative, original thought. The advantage of having a limited number (2-3) of sustained research experiences are many; not only is one able to play a substantial role in an in-depth project, your recommenders will be able to write letters with depth, commenting on your personality, motivation, as well as capacity for original though. Having a few advocates that can comment with depth would be to ones advantage. Purely anecdotally, I had 3 different research experiences; one which was very short beginning in my freshman year (2nd semester), and my mentor served as my advisor throughout college, even as I worked in other labs. Starting my sophomore year, I began working in another lab at college, which I continued throughout college. During each of the summers I spent my time at a Pharmaceutical, doing research in one lab for 3 summers, in a very different field from the other two experiences. Some successful applicants have as little research experience as a couple summers, while others spend a year or more after graduation pursuing research projects.

Sean’s additional comments:
I think that to a certain extent the relationships that you build with the particular institution that you have conducted research at is at much of an asset as the actual research experience itself. Personally I think that working at a variety of institutions and at a variety of geographical locales are very nice additions both from a scientific career standpoint and a personal development standpoint. However, it is more likely that you’d be able to accomplish more as a researcher if you stick to a single lab that you perform well in. It is much easier to get publications, sometimes multiple publications, that way.Back to top

Will excellent research experience make up for a lack of clinical experience?

While some candidates often have a lot of medical experience, it is often the case that MD/PhD will have more research heavy applications. While it is important to have as much research experience as possible, one must not lose sight of the expectations of a dual degree program. Without any clinical exposure at all, it will be difficult to convince someone that you understand what sort of knowledge a medical education will add to your training. More importantly, the experience would aid ones ability to think in a more sophisticated manner regarding how a dual degree would enhance your training and subsequent effectiveness in an academic career. While excellent research experiences can certainly overshadow minimal clinical experience, the best candidates will be able to reference experiences in both worlds with ease, based on the time they have spent.

Sean’s additional comments: You often get asked what clinical exposures have you had, be prepared to answer questions of that sort. Back to top

Does the reputation of my college matter?

This is an often-debated question in both medical admissions as well as md/phd admissions. Empirical evidence from those that get interviews at the top programs show that more students from better schools get interviews than from lesser known schools. This is certainly multi-factorial and a mix of caliber of student a college usually receives, and the education that they receive while there. Furthermore, schools are occasionally more forgiving with regards to GPA or other factors if one comes from a highly reputable undergraduate college in order to get an interview, though admission is dependent on the interview itself. Nevertheless, with strong scores, research, clinical and extra curricular experience, it is possible to gain admission at the best programs. Even without a flawless record, strong research experience and excellent interviewing skills can certainly show that you are an excellent candidate regardless of your school.

Sean’s comments:
Personally I strongly believe that the overall package of the applicant, particularly the MCAT/GPA + research experience can render the “reputation” of the college almost negligible. I’ve met many successful applicants from schools that are outside of the scope of the top 25 schools in the USNews ranking, using it strictly as a list. It’s difficult to say whether someone from a highly competitive school gets a boost on the GPA, but people who with excellent records from somewhat less well-known (particular large public) universities should not worry at all about this issue. Back to top

What kind of scores do I need?

Again, this is one of the most oft asked questions in this process. Before any numbers are discussed, it is important to reiterate that even average numbers of a program are highly conditional on the applicant, and their circumstances. Secondly, it is important to note that the higher numbers associated with MSTP programs are mostly due to self-selection of students. The national MCAT average for MSTP programs is 35, and average GPA is around a 3.7. Some of the most competitive programs have averages around 36/3.8, while other well established MSTP’s have averages around 33/3.65. Washington University, for example, advertises a range of scores from 29 to 42 in one years class. Excellent research or extra-curricular experience can compensate for lower scores, though they have to be within a reasonable range in order to get an interview. Back to top

What are the programs looking for in an applicant?

While a strong scholastic record is requisite for these programs, your commitment, depth of understanding, and creativity in research is perhaps even more important. Furthermore, it is equally important to have a cogent reason for wanting to pursue the dual degrees. This must come across in your essays, and especially in your interviews. Furthermore, it is important not to neglect other aspects of your application, interesting extra-curricular activities, athletics, music, organizations, leadership etc…, because in a field of highly competitive students, your character and experience will make you stand out. Back to top

How competitive is it to get into these programs?

There are approximately 400-500 applicants to the ‘most-applied-to-programs’, however, this number is only increasing. From 2002 to 2003, there was a 45% increase in applicants at some schools. When there are on average 8-10 NIH funded spots at each school, these numbers may seem daunting. It is important to remember, however, that the same people tend to apply to the same schools. An administrator at a top rated MSTP program approximated that there were about 800 MSTP applicants nationwide that particular year, and about half of them were reasonably competitive. With about 350-400 MSTP funded slots available nationwide, and even more fully funded MD/PhD slots, one begins to realize that much of the application process is matching the right student with the right school. Obviously, competition will be most intense at the elite programs, but it is important to remember that all MSTP-NIH funded programs are of high quality, and worth pursuing dual degrees at.
After one applies, the largest cut is made pre-interview, and those that receive an interview invitation have a high chance (ranging from 25-66%) of admittance. Since it is a matching process for student and school, 10 available seats does not mean that there are only 10 acceptances given out. Often 2-3 times the number candidates than spots available are eventually accepted.

Sean’s Additional comments: Jeremy Cholfin (UCSF MSTP) was really right when he analyzed the admissions patterns. It doesn’t follow conventional thinking sometimes. I think it is important to point out that one should not be discouraged when one is rejected or put on the waitlist early on by a “less-competitive” school, particularly if one has many interviews. Back to top

Where should I apply?

While it may seem initially reasonable to apply to as many schools as possible to increase ones chances of ‘matching’ to a program, there are a number of reasons why this is not recommended. Foremost, the financial cost of applying to a high number of schools is very high. Applying to 20 schools will cost about $800 for the primary application, ~$80 for each secondary application, and since most schools do not pay for the cost of traveling and/or lodging in recent years due to the high number of students interviewed, it could cost up to $500 an interview. With application fees reaching close to $10,000, it makes sense to be more judicious for this reason alone. If, however, one is fortunate enough for this not to be a problem, the sheer time it takes to complete an application is worth considering. After the primary application, which is the same for most schools (notable exceptions are Columbia, NYU etc…), secondary applications as well as MD/PhD supplemental need to be completed. Since this is the only way schools are going to be able to attach a personality to your numbers, it is important to take time and energy to present yourself in the best light. Since the essay questions for the secondaries vary greatly from school to school, it is important not to underestimate the time required to complete them (though they should not require as much attention as the primary). Now that you may have realized not to apply to every MSTP, there are important ways to narrow down programs. See What should I look for in a program?

Sean’s additional comments: For those who are more spendthrift: for some reason I didn’t spend nearly that much money (i.e. $10000) despite the fact that I applied to ~20 schools. Many of the schools I’ve interviewed at paid for airfare and I stayed with students as much as possible to cut expenses. Overall I spent $2500 at most, and most of it thankfully was covered through my summer job. Also, I filed applications for many extremely competitive schools, and was (by chance, if nothing else) rejected pre-interview. I think if you have ~$3000 to spare, try to apply to a reasonable number of schools, particularly if you are shooting for the very top tier schools. Back to top

Is there a suggested timeline for applicants?

Earlier is always better! Especially for MSTP, one should aim to take the April MCAT for starters. There is a long-standing debate about exactly how much taking the August disadvantages the applicant, but if one must take it, it certainly will not disqualify an applicant. Make sure that if your undergrad has a pre-medical letter writing committee, all materials are submitted early. Recommendations should be obtained towards the end of the spring, and it is a good idea to use a letter-distribution service if possible. Submit the AMCAS primary application as early as possible – one should aim to have this done by the end of July (the application becomes available in May). Secondaries from schools will either already be available online, or sent to an early applicant by mid-august. Most secondaries do not change from year to year, and it is a good idea to start thinking about the questions in previous years applications in preparation. Recommendations are submitted with secondaries, as well are individual application fees. If one has applications submitted by august/September/early-October, it will be possible to attend the earliest interview dates at schools, or at least have ones pick at scheduling. While there is a slight advantage to interviewing early in the application season, dates into January/February will not put applicants at any discernable disadvantage (at rolling-schools). At non-rolling schools, all interview dates are equally viable. The interview season usually begins to wrap up around mid/late February at most schools, though some interview into March.
Be judicious about calling schools about your application status. While MSTP administrators are usually much friendlier than their MD counterparts (understandably, small number of applicants), you should only call if you are unsure whether or not your application is complete, or have not heard anything from the school for 6-8 weeks after your application is complete. Be considerate and understanding, these people may be taking care of you for the next 6-8 years! Back to top

Should I include my interests in research in my AMCAS personal statement?

Definitely! Always remember, however, that the AMCAS application is mainly for the medical school. There will be an opportunity to write an MD/PhD specific personal statement later in the process. Careful construction of ones personal statement will highlight ones interest in medicine foremost, strengthened by experience and intentions to pursue a career in academic medicine. Personal statements are not meant to be formulaic, and successful statements have had all, some, or limited aspects of the above elements. Take this opportunity to present past experiences in an interesting manner, while incorporating a cohesive thematic element. Even though MD/PhD applications usually go straight to MD/PhD admissions committees for evaluation, some schools (UCSF/Harvard) conduct separate MD and MSTP admissions processes, and this is just another aspect of an applicants package that must appeal to both sides. Back to top

How important is the secondary information such as the specific medical school essays and MD/PhD essays?

Realize that prior to this information, all schools know of an applicant are their scores, and the limited personal information that can be gleaned from the personal statement. Most schools – though there are some exceptions (Harvard/UPenn etc…) – have short essays on various topics, from describing ethical dilemmas, to writing relatively short autobiographies. There are many occasions to provide optional essays, and this opportunity should be used to paint a more complete image of you as an applicant. Do not spend an excessive amount of time on the secondaries; the main objective should be efficiently and effectively completing applications.
The MD/PhD personal statement, on the other hand, should be carefully constructed. Not only should it address why MD/PhD, but also detail prior research experiences. It is best to write the statement in a modular fashion (why MD/Phd / each research experience) because while some schools simply request a personal statement, others request these issues to be addressed separately. While most people are pursuing and md/phd because they enjoy medicine, research, and perhaps teaching – it is important to dig deeper for a more personal reason. While describing research experiences, assume that the reader is fairly knowledgeable about your topic, but make an effort to place it in the larger context of how it encouraged an interest in pursuing the dual degrees. Furthermore, make sure to highlight personal contributions to the work, emphasizing intellectual contributions and creativity in thought. Though the statement is research-centric, it is essential to justify the necessity of the medical degree – this question will arise on countless occasions. Back to top

How much will the process cost me, and how much time will it take?

The cost of the process is highly dependent on how many schools one applies to. The initial cost of the AMCAS application is around $200, and each school added is $30. Secondary fees are ~$70/school. Unless a school pays for interview expenses (this is becoming increasingly rare – Midwest schools tend to do this more often for the purposes of recruiting), the cost of a flight must be factored in. This should be taken into consideration when considering how many schools to apply to on another coast (if you reside on the east or west coast). Whenever possible request a student host. Besides allaying the cost of a hotel, they will be able to provide you a valuable perspective on the program, and possibly on members of the committee who are interviewing you. Be considerate to your student hosts!
Luckily, you have chosen one of the longest application processes possible. Learn to enjoy, or at least deal with waiting, or the experience will be rather nerve-racking. Not hearing from a school on the first day possible is not a silent commentary on the competitiveness your application. The interviews are time consuming, and expect to take time out of work/school. Almost all schools interview on the weekdays, usually any combination of Thurs/Fri or Mon/Tues. Traveling time is substantial and it can quickly become a logistical problem to schedule numerous interviews. West-coast applicants should attempt to group interviews in the same region together in order to save time and money. Back to top

How should I prepare for an interview?

There are two standard pieces of information that every applicant will be asked for many times! Why MD/PhD? Explain your research. Secondly, don’t forget that in addition to meeting with the MD/PhD committee, at most schools there will also be medical school interviews. All frequently asked questions for straight-MD applicants also apply.
At most interviews, there will be time at the beginning of the conversation for you to speak directly to the aforementioned questions. An excellent strategy is to weave your past medical and research experiences into a coherent story that corroborates with your decision to pursue the dual degrees. Lasting about 2-4 minutes, it should contain in it all the ‘hooks’ that you would like to steer the conversation into. Though the preceding language may unintentionally imply contriving a story (certainly not the case!) – it is important to focus the interview on issues/research topics that are most familiar, relevant and conducive to endorsing your candidacy. As a general rule, not limited to MD/PhD interviews, it is important to gauge ones audience. The depth of detail should be adjusted for those in your field, other scientists, as well as medical doctors.
An excellent way to prepare for interviews with regard to research knowledge is to take reviews in of a specific field, and branch off the papers it cites. Repeat. Make sure to keep knowledge current as the interview season progresses!
An important piece of advice was imparted upon me before I began interviewing: “Interested is interesting”. While it is important not to present an affected personality, body language, enthusiasm, tenor and demeanor are as essential to interviewing as the content itself. Back to top

What are the interviews like, and how are they structured?

For the most part, interviews are extremely pleasant experiences. While it may not feel like it at the time, they are an opportunity for a school to impress an applicant as much as for an applicant to impress them. MD/PhD interviews may occur over 1 or 2 days, and usually include a time for the medical school to inform and interview as well as an MD/PhD only segment. Interviews with the MD/PhD are usually divided into those with committee members (one on one or panel) and those with scientists in the applicant’s specific field.
Many applicants go into their first interviews ready to be antagonized about minutiae tangentially related to their research, this is certainly not the case. These interviews are simply relaxed conversations. There may be challenging questions presented, but they are usually within the scope of ones specific research field, and even then, it is ok to simply not know the answer. In case of the latter, it is very important to admit lack of knowledge rather than BSing through an answer. It is important to view your interviewer as your advocate at an MD/PhD admissions committee meeting. Presenting them with the information and conviction they need to endorse you will allow an applicant to stand out in a field of highly qualified people.
Occasionally, an interview will be rather stressful, but it is important to keep calm and steer the conversation into familiar topics. Oftentimes, these interviews go much better than they are perceived. There is no point second-guessing the motives of the interviewer, or how they report back to the committee.
In addition to the interviewing portion of a program visit, there will be opportunities to meet current students, go out for dinner, see the surrounding areas, and assess other factors. For tips on what to look for, seeWhat should I look for in a program?
There is much more information about specific programs, and more general interviewing tips interspersed throughout the Program Review section. Back to top

What should I look for in a program?

Things to think about when Interviewing, questions to ask:
While each applicant has differing priorities-here are some things that were important to me while interviewing (no particular order):

Program Philosophy: Not all MD/PhD programs are created equally, and they certainly all aren't created with the same goals and visions on mind. For example, Duke is interested in training PHYSICIAN-scientists while Hopkins usually trains physician-SCIENTISTS. Attitudes to the graduate years and clinical years differ greatly, often at the vision of the current program director. Secondly, IS there a program to begin with - some schools have the mstp in periphery; while the 2 degrees are in the forefront, while others are well integrated. Though this is ancillary to the program philosophy, pay attention to the administrator and director. Do they care about the program? If you have a problem, can they do something about it? Can you get along with them; you will have extensive interaction with them in the future.

Location: You will be spending 7-8 years in a place. For many of us, this is during the bulk of our 20's. Are you looking to settle down in a quiet area, live it up in a big city, or find a compromise - an area with amenities of both? While I think it is reasonable to spend 4 years of medical school just about anywhere, this becomes more of factor for us md/phd wannabes. This includes the quality of life factor - while some smaller places do not have as much excitement, you can live like a king on your stipend, while in NYC for instance, you will not be driving that Hummer you always wanted.

Research: While it is imperative to examine the program structure etc... There is hardly a point if the research you want to pursue is not represented at the school. Depending on the importance of this on your priority list - for most people it is very high - it can trump many other factors in your decision. Look at the 'big names' at the school, but also look at the younger researchers. Is there new and innovative research, or are the investigators coming to the end of their careers? What are the schools basic science strengths, and how do they compare nationally. While it is only necessary to find one good mentor and investigator, your thesis advisor, the advantage to have excellence all around you is in the culture of the institution. The lecturers that come through will be varied, and the interaction you will have will be enriching. All schools boast a highly collaborative nature of their research community, but don't accept this until you see proof in the form of journal articles.

Medical School: At first I didn't think that the medical curriculum really mattered; everyone takes the boards, and at the top schools, for the most part, everyone does well. While interviewing, however, my perspective on this changed quite a bit. With regards to MSTP training, it is extremely useful to experience patient interaction before the 3rd year. While most schools tout this feature, those that feature 1.5 year basic science curriculums, with 6 months of clinical rotations allow for excellent clinical experience before one begins their thesis work. Other factors to consider are traditional lecture based curriculums versus problem based learning (PBL/tutorial) setups, though most school fall at some happy medium in that continuum. Though it is often hard to gauge when shopping around for schools, finding a good fit in terms of classmates will enhance the experience a great deal. Other factors such as locations of hospitals, and accessibility of faculty should be considered, though there isn’t a great differential amongst the top schools.

Nebulous Gut Feeling: This is extremely important - perhaps the most important. All those subconscious factors you don't want to consciously articulate culminate into a gut feeling toward a place. While I would try to remain somewhat objective about a place, there is no point forcing down chocolate cake just because you know everyone else loves it. Allow a second visit to reshape your feelings, but ask yourself, 'do I fit in here?'" Back to top

What programs are available for International students?

Though NIH funded MSTP seats are meant for permenant residents and citizens of the United States, many MSTP funded schools have mechanisms which allow them to accept non-citizens. These funding mechanisms are usually institutionally or privately derived, and therefore, limited. An excellent international candidate should have no trouble being accepted to a program if one applies wisely. Furthermore, many schools do not have an official policy on international students, and handle them on a case-by-case basis. If you are very interested in a particular program, it would be worth contacting the administrator/director to see if the program has any 'wiggle room'. The following schools have accepted international students in the past. If a school does not appear on this list, and should, please e-mail
If there are any other specific questions international students would like to see addressed, please e-mail the address above.

Northwestern University
Harvard University (Presidential Scholars)
Johns Hopkins University (1 Merck fellowship)
Washington University in St. Louis (multiple seats)
Duke University
University of Pennsylvania
Columbia U. College of Physicians and Surgeons
Yale University (usually one spot)
Baylor College of Medicine
Cornell University (Tri-Institutional program)
U. of Texas Southwestern Medical CenterñDallas (multiple seats)
Emory University
University of Chicago
Mount Sinai School of Medicine
Yeshiva University (Albert Einstein)
Dartmouth Medical School
University of Southern California
University of MinnesotañTwin Cities
Indiana UniversityñIndianapolis
Tufts University
University of Connecticut
Vanderbilt
SUNY Upstate
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